Genetic variant

rs149212747

rs149212747 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs149212747 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Genomewide association study of alcohol dependence and related traits in a Thai population.

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs149212747, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs149212747
Position
chr12:111398967

Genome-wide association studies (19)

TraitRisk alleleOR / betaP-valueStudy
HDL cholesterol levels AC OR 1.32 2E-42 PubMed
Colorectal cancer — OR 0.17 4E-18 PubMed
MCHC x ever-drinking interaction AC β 0.09 1E-17 PubMed
Hb x ever-drinking interaction AC OR 0.13 2E-16 PubMed
MCHC x commonly-tested environments (Sex, Age, Ever-drinking, Ever-smoking, and Current-smoking) interaction AC — 2E-15 PubMed
Hb x all environments (Sex, Age, Ever-drinking, Ever-smoking, Current-smoking, Japanese cuisine, European cuisine, Dairy products, and Physical activity) interaction AC — 3E-13 PubMed
Alcohol consumption (max-drinks) A OR 0.59 2E-12 PubMed
Hb x commonly-tested environments (Sex, Age, Ever-drinking, Ever-smoking, and Current-smoking) interaction AC — 2E-12 PubMed
Type 2 diabetes A OR 1.07 2E-11 PubMed
MCHC x all environments (Sex, Age, Ever-drinking, Ever-smoking, Current-smoking, Japanese cuisine, European cuisine, Dairy products, and Physical activity) interaction AC — 4E-11 PubMed
Hematocrit x ever-drinking interaction AC OR 0.27 4E-10 PubMed
Triglycerides AC β 0.031 4E-10 PubMed
Alcohol dependence symptom count A OR 0.91 6E-10 PubMed
Epilepsy — OR 1.38 9E-10 PubMed
Non-HDL cholesterol levels AC β 0.042 1E-9 PubMed
Hematocrit x all environments (Sex, Age, Ever-drinking, Ever-smoking, Current-smoking, Japanese cuisine, European cuisine, Dairy products, and Physical activity) interaction AC — 2E-9 PubMed
Colorectal cancer — OR 1.15 5E-9 PubMed
LDL cholesterol levels AC OR 1.41 1E-8 PubMed
Hematocrit x commonly-tested environments (Sex, Age, Ever-drinking, Ever-smoking, and Current-smoking) interaction AC — 6E-8 PubMed

Sources