Genetic variant
rs1490384
rs1490384 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1490384 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1490384, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1490384
- Position
- chr6:126530014
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Standing height (UKB data field 50) | T | β 0.028 | 2E-179 | PubMed |
| Height | T | β 0.054 | 1E-169 | PubMed |
| Height | — | — | 3E-166 | PubMed |
| Height (baseline) | C | β 0.033 | 1E-144 | PubMed |
| Height | — | β 0.044 | 8E-141 | PubMed |
| Physical function (baseline) | C | β 0.022 | 7E-93 | PubMed |
| Body size (confirmatory factor analysis Factor 21) | — | — | 2E-82 | PubMed |
| Brain morphology (MOSTest) | — | — | 8E-65 | PubMed |
| C-reactive protein levels | C | β 0.029 | 9E-45 | PubMed |
| C-reactive protein levels | T | β 0.028 | 1E-42 | PubMed |
| C-reactive protein levels (MTAG) | T | β 0.027 | 1E-41 | PubMed |
| Brain morphology (MOSTest) | — | — | 1E-38 | PubMed |
| C-reactive protein levels (UKB data field 30710) | T | β 0.025 | 3E-38 | PubMed |
| C-reactive protein | T | β 0.031 | 2E-37 | PubMed |
| Forced expiratory volume (baseline) | C | β 0.021 | 7E-36 | PubMed |
| Total bilirubin levels (UKB data field 30840) | T | β 0.015 | 7E-22 | PubMed |
| Total bilirubin levels | T | β 0.025 | 9E-22 | PubMed |
| Height | T | β 0.034 | 4E-21 | PubMed |
| Smoking initiation | T | β 0.007 | 7E-18 | PubMed |
| Smoking initiation | T | β 0.007 | 9E-18 | PubMed |
Sources
- dbSNP: rs1490384 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies