Genetic variant
rs1487441
rs1487441 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1487441 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1487441, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1487441
- Position
- chr6:98106018
Genome-wide association studies (12)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Occupational income | — | β 0.024 | 2E-28 | PubMed |
| Fluid intelligence score (baseline) | G | β 0.028 | 1E-26 | PubMed |
| Free cholesterol in very large HDL | A | β 0.02 | 1E-23 | PubMed |
| Creative achievement | G | β 0.021 | 4E-23 | PubMed |
| Triglycerides to Total Lipids in Very Large HDL percentage | A | β 0.01 | 6E-15 | PubMed |
| Haematocrit percentage (UKB data field 30030) | A | β 0.013 | 5E-14 | PubMed |
| Cholesterol to Total Lipids in Large HDL percentage | A | β 0.01 | 2E-13 | PubMed |
| Occupational creativity | G | β 0.049 | 2E-12 | PubMed |
| Mental health study participation (provided email address) | A | β 0.007 | 1E-11 | PubMed |
| Educational attainment | A | β 0.026 | 2E-9 | PubMed |
| Bipolar disorder | G | OR 1.12 | 3E-8 | PubMed |
| Managerial occupational creativity | G | β 0.044 | 3E-8 | PubMed |
Sources
- dbSNP: rs1487441 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies