Genetic variant
rs13428598
rs13428598 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs13428598 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Biological annotation of genetic loci associated with intelligence in ameta-analysis of 87,740 individuals
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs13428598, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs13428598
- Position
- chr2:143492918
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Educational attainment (MTAG) | T | β 0.015 | 1E-29 | PubMed |
| Highest math class taken (MTAG) | T | β 0.015 | 2E-19 | PubMed |
| CAMSIS occupational score (MTAG) | — | β 0.016 | 4E-19 | PubMed |
| Cognitive performance (MTAG) | T | β 0.021 | 1E-18 | PubMed |
| diastolic blood pressure (DBP, mean, inv-normal transformed) | C | β 0.026 | 2E-18 | PubMed |
| ISEI occupational score (MTAG) | — | β 0.014 | 8E-18 | PubMed |
| SIOPS occupational score (MTAG) | — | β 0.013 | 1E-17 | PubMed |
| Educational attainment (years of education) | — | — | 4E-16 | PubMed |
| Intelligence (MTAG) | T | β 0.023 | 4E-13 | PubMed |
| Percentage of invited food questionnaires completed | C | OR 0.65 | 1E-12 | PubMed |
| Cognitive performance | T | β 0.02 | 1E-11 | PubMed |
| Cognitive aspects of educational attainment | C | β 0.044 | 2E-11 | PubMed |
| Fluid intelligence score (baseline) | C | β 0.018 | 5E-11 | PubMed |
| General cognitive ability | T | OR 5.94 | 3E-9 | PubMed |
| Extremely high intelligence | T | OR 5.85 | 5E-9 | PubMed |
| Verbal-numerical reasoning | — | — | 5E-9 | PubMed |
Sources
- dbSNP: rs13428598 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies