Genetic variant
rs13141641
rs13141641 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs13141641 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs13141641, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs13141641
- Position
- chr4:144585304
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lung function (FEV1/FVC) | T | β 0.07 | 4E-184 | PubMed |
| Peak expiratory flow | T | β 0.061 | 7E-126 | PubMed |
| FEV1 | T | β 0.035 | 4E-48 | PubMed |
| Chronic obstructive pulmonary disease | T | OR 1.22 | 9E-41 | PubMed |
| Hip shape mode 2 | T | β 0.08 | 2E-33 | PubMed |
| Chronic obstructive pulmonary disease | C | β 0.06 | 7E-24 | PubMed |
| Chronic airway obstruction (PheCode 496) | T | β 0.047 | 2E-22 | PubMed |
| Post bronchodilator FEV1/FVC ratio | T | β 0.018 | 1E-19 | PubMed |
| Emphysema distribution in smoking | T | OR 0.12 | 6E-18 | PubMed |
| Emphysema (PheCode 496.1) | T | OR 0.11 | 2E-15 | PubMed |
| Emphysema (PheCode 496.1) | T | OR 0.11 | 3E-15 | PubMed |
| Chronic obstructive pulmonary disease (severe) | T | OR 1.39 | 4E-15 | PubMed |
| Post bronchodilator FEV1 | T | β 0.072 | 4E-14 | PubMed |
| T1 brain MRIs Unsupervised Deep learning derived Imaging Phenotypes (dimension 13) | — | — | 6E-14 | PubMed |
| Chronic obstructive pulmonary disease (moderate to severe) | T | OR 1.27 | 2E-12 | PubMed |
| Emphysema imaging phenotypes | T | OR 2.2 | 8E-10 | PubMed |
| Post bronchodilator FEV1/FVC ratio in COPD | T | β 0.012 | 3E-7 | PubMed |
| Chronic obstructive pulmonary disease | T | OR 1.39 | 3E-7 | PubMed |
| Chronic obstructive pulmonary disease | — | OR 1.32 | 3E-7 | PubMed |
| Chronic bronchitis and chronic obstructive pulmonary disease | T | OR 1.27 | 3E-6 | PubMed |
Sources
- dbSNP: rs13141641 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies