Genetic variant
rs13107325
rs13107325 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs13107325 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs13107325, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs13107325
- Position
- chr4:102267552
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| sMRI-derived phenotypes (MOSTest) (pleiotropy) | — | — | 5E-324 | PubMed |
| Pallidum iron levels (quantitative susceptibility mapping) | C | OR 0.42 | 2E-231 | PubMed |
| Substantia nigra iron levels (quantitative susceptibility mapping) | C | OR 0.39 | 2E-197 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | C | OR 0.16 | 1E-193 | PubMed |
| High density lipoprotein cholesterol levels | — | — | 1E-185 | PubMed |
| Vertex-wise cortical thickness | T | OR 28.2 | 6E-175 | PubMed |
| high density lipoprotein cholesterol (HDLC, minimm, inv-norm transformed) | C | OR 0.15 | 8E-174 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | C | OR 0.14 | 3E-171 | PubMed |
| Brain morphology (MOSTest) | — | — | 6E-169 | PubMed |
| Caudate iron levels (quantitative susceptibility mapping) | C | OR 0.35 | 1E-167 | PubMed |
| SDC1 protein levels | T | OR 0.28 | 5E-165 | PubMed |
| Pallidum iron levels (R2* MRI) | C | OR 0.34 | 2E-153 | PubMed |
| Liver fibrosis and steatohepatitis severity (MRI cT1 measure) | T | OR 0.54 | 1E-133 | PubMed |
| High-density lipoprotein levels | T | OR 0.12 | 1E-131 | PubMed |
| Substantia nigra iron levels (R2* MRI) | C | OR 0.32 | 6E-127 | PubMed |
| SLITRK2 protein levels | T | OR 0.22 | 6E-127 | PubMed |
| Whole brain restricted isotropic diffusion (multivariate analysis) | — | — | 6E-125 | PubMed |
| Brain morphology (MOSTest) | — | — | 3E-124 | PubMed |
| IDP T1 FAST ROIs L ventral striatum | T | OR 0.43 | 1E-119 | PubMed |
| High density lipoprotein cholesterol levels | T | β 0.078 | 5E-118 | PubMed |
Sources
- dbSNP: rs13107325 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies