RS12979860 IFNL4

Drug Response Chr 19:39248146 snv intron variant

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What This Variant Does

"rs12979860 is a SNP near the IL28B gene, encoding interferon-lambda-3 (IFN-lambda-3). Several studie...

Associated Conditions

peginterferon alfa-2a

peginterferon alfa-2b

ribavirin

and telaprevir response - Efficacy

and ribavirin response - Efficacy

boceprevir

peginterferon alfa-2b and ribavirin response - Efficacy

peginterferon alfa-2a

peginterferon alfa-2b

ribavirin

and telaprevir response - Efficacy

and ribavirin response - Efficacy

boceprevir

peginterferon alfa-2b and ribavirin response - Efficacy

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
Chronic hepatitis C infection	—	OR: 2.2	2E-30	PubMed
Response to hepatitis C treatment	C	OR: 2	1E-28	PubMed
Ovarian cyst	T	β: 0.085	2E-8	PubMed

Population Frequencies

gnomAD ALL

28.2%

1kG AFR

33.1%

1kG ALL

64.4%

1kG AMR

39.9%

1kG EAS

92%

1kG EUR

69.1%

1kG SAS

23.3%