Genetic variant
rs12614
rs12614 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12614 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12614, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12614
- Position
- chr6:31946402
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Neutrophil collagenase levels (MMP8.2954.56.2) | T | OR 1.33 | 1E-283 | PubMed |
| Neuregulin-1, sensory and motor neuron-derived factor isoform level in Chronic kidney disease with hypertension and no diabetes (15446_25) | T | OR 1.1 | 7E-115 | PubMed |
| Neuregulin-1, sensory and motor neuron-derived factor isoform levels | T | OR 0.82 | 1E-107 | PubMed |
| Neutrophil collagenase level in Chronic kidney disease with hypertension and no diabetes (2954_56) | T | OR 1 | 2E-81 | PubMed |
| Trimeric intracellular cation channel type B level in Chronic kidney disease with hypertension and no diabetes (9509_4) | T | OR 0.82 | 2E-44 | PubMed |
| Trimeric intracellular cation channel type B levels | T | OR 0.28 | 5E-36 | PubMed |
| Chronic hepatitis B infection | T | OR 1.89 | 1E-34 | PubMed |
| Beta-defensin 113 levels | T | OR 0.27 | 2E-31 | PubMed |
| FNTA protein levels | T | OR 0.13 | 1E-30 | PubMed |
| Gremlin-1 levels | T | OR 0.36 | 1E-29 | PubMed |
| Neuregulin-1, sensory and motor neuron-derived factor isoform levels | T | OR 0.25 | 2E-26 | PubMed |
| Gremlin-1 levels (GREM1.4449.67.3) | T | OR 0.44 | 7E-25 | PubMed |
| Rheumatoid arthritis or type 1 diabetes | — | — | 2E-21 | PubMed |
| Delta and Notch-like epidermal growth factor-related receptor:Cytoplasmic domain protein levels (SomaScan ID:2954-56) | T | OR 1.3 | 2E-14 | PubMed |
| Beta-defensin 116 levels | T | OR 0.16 | 9E-12 | PubMed |
| Linoleic acid levels | T | — | 1E-11 | PubMed |
| Serum levels of protein CFB | T | OR 0.24 | 2E-11 | PubMed |
| Omega-6 fatty acid levels | T | — | 5E-11 | PubMed |
| Total cholesterol levels | T | β 0.054 | 7E-11 | PubMed |
| Non-HDL cholesterol levels | T | β 0.05 | 5E-8 | PubMed |
Sources
- dbSNP: rs12614 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies