Genetic variant

rs1260333

rs1260333 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1260333 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1260333, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1260333
Position
chr2:27525757

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Triglyceride levels in non-type 2 diabetes — — 2E-307 PubMed
Triglyceride levels — β 0.047 9E-31 PubMed
Triglycerides A β 0.022 2E-21 PubMed
EGFR/FAP protein level ratio — β 0.06 6E-20 PubMed
Triglycerides C β 0.05 2E-19 PubMed
Phosphatidylcholine-O_34:1_[M+H]1+/Phosphatidylcholine-P_34:0_[M+H]1+/Phosphatidylethanolamine-O_37:1_[M+H]1+ levels A β 0.093 5E-16 PubMed
Estimated glomerular filtration rate G OR 0.53 2E-15 PubMed
White blood cell count G β 0.024 1E-12 PubMed
Total cholesterol levels — OR 2.47 3E-12 PubMed
Sphingomyelin_34:1_[M+H]1+ levels A β 0.083 6E-12 PubMed
Phosphatidylcholine-O_32:1_[M+H]1+/Phosphatidylcholine-P_32:0_[M+H]1+/Phosphatidylethanolamine-O_35:1_[M+H]1+ levels A β 0.082 8E-12 PubMed
Diacylglycerol_44:7_[M+H-H2O]1+ levels A β 0.079 1E-11 PubMed
Sphingomyelin_34:0_[M+H]1+ levels A β 0.079 1E-11 PubMed
Phosphatidylcholine-O_31:0_[M+H]1+/Phosphatidylethanolamine-O_34:0_[M+H]1+ levels A β 0.077 3E-11 PubMed
Diacylglycerol_34:3_[M+H-H2O]1+ levels A β 0.068 2E-10 PubMed
Diacylglycerol_32:2_[M+H-H2O]1+ levels A β 0.072 3E-10 PubMed
Phosphatidylcholine-O_30:1_[M+H]1+/Phosphatidylcholine-P_30:0_[M+H]1+/Phosphatidylethanolamine-O_33:1_[M+H]1+ levels A β 0.069 4E-10 PubMed
Phosphatidylcholine-O_34:3_[M+H]1+/Phosphatidylcholine-P_34:2_[M+H]1+/Phosphatidylethanolamine-P_37:2_[M+H]1+ levels A β 0.076 4E-10 PubMed
Cholesterol, total A OR 1.77 3E-8 PubMed
Renal underexcretion gout A OR 1.37 5E-7 PubMed

Sources