Genetic variant
rs1260326
rs1260326 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1260326 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The T allele of rs1260326 has been associated with type 2 diabetes and hypertriglyceridemia. A fine ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1260326, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1260326
- Position
- chr2:27508073
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglyceride levels | — | — | 7E-1473 | PubMed |
| Triglyceride levels | C | OR 0.11 | 7E-878 | PubMed |
| Triglycerides in small HDL | C | OR 0.11 | 7E-644 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | C | OR 0.11 | 2E-628 | PubMed |
| Total lipids in small HDL | C | OR 0.11 | 4E-602 | PubMed |
| Triglycerides in small VLDL | C | β 0.1 | 2E-594 | PubMed |
| Triglycerides to Total Lipids in Very Large HDL percentage | C | β 0.1 | 6E-588 | PubMed |
| Phospholipids in small HDL | C | OR 0.11 | 3E-578 | PubMed |
| Triglycerides in medium LDL | C | β 0.1 | 2E-571 | PubMed |
| Monounsaturated fatty acid levels | C | OR 0.11 | 1E-565 | PubMed |
| Triglycerides in very small VLDL | C | β 0.1 | 6E-543 | PubMed |
| Triglycerides in small LDL | C | β 0.1 | 4E-538 | PubMed |
| Triglycerides in HDL | C | β 0.1 | 2E-515 | PubMed |
| Triglycerides | C | β 0.099 | 3E-515 | PubMed |
| Glycoprotein acetyls levels | C | β 0.1 | 1E-513 | PubMed |
| Triglycerides in LDL | C | β 0.1 | 1E-512 | PubMed |
| Free cholesterol in small HDL | C | β 0.1 | 4E-512 | PubMed |
| Free Cholesterol to Total Lipids in Large LDL percentage | C | β 0.09 | 1E-509 | PubMed |
| Total triglycerides levels | C | β 0.1 | 4E-506 | PubMed |
| Triglycerides in medium HDL | C | β 0.1 | 9E-503 | PubMed |
Sources
- dbSNP: rs1260326 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies