Genetic variant
rs1257169
rs1257169 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1257169 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
MGAT5 and disease severity in progressive multiple sclerosis
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1257169, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1257169
- Position
- chr2:134206291
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| VCAM1 protein levels | A | β 0.094 | 1E-70 | PubMed |
| ADGRE1 protein levels | A | β 0.093 | 2E-68 | PubMed |
| Scavenger receptor cysteine-rich type 1 protein M130 levels | A | OR 0.22 | 1E-59 | PubMed |
| LILRA2 protein levels | A | β 0.065 | 2E-51 | PubMed |
| CR1 protein levels | A | β 0.075 | 6E-51 | PubMed |
| LILRB1 protein levels | A | β 0.063 | 6E-46 | PubMed |
| Vascular cell adhesion protein 1 levels | A | OR 0.14 | 2E-25 | PubMed |
| Interleukin-27 levels | A | β 0.09 | 2E-24 | PubMed |
| SIGLEC7 protein levels | A | β 0.053 | 1E-23 | PubMed |
| AXL protein levels | A | β 0.043 | 3E-16 | PubMed |
| LILRB2 protein levels | A | β 0.032 | 3E-16 | PubMed |
| MRC1 protein levels | A | β 0.042 | 3E-15 | PubMed |
| SIGLEC10 protein levels | A | β 0.041 | 9E-15 | PubMed |
| GAS6 protein levels | A | β 0.038 | 2E-14 | PubMed |
| SIGLEC5 protein levels | A | β 0.033 | 1E-13 | PubMed |
| MSR1 protein levels | A | β 0.033 | 1E-11 | PubMed |
Sources
- dbSNP: rs1257169 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies