Genetic variant
rs12459419
rs12459419 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12459419 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Clinical Significance of CD33 Nonsynonymous Single-Nucleotide Polymorphisms in Pediatric Patients with Acute Myeloid Leukemia Treated with Gemtuzumab-Ozogamicin-Containing Chemotherapy
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12459419, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12459419
- Position
- chr19:51225221
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Myeloid cell surface antigen CD33 levels | T | OR 0.94 | 3E-1638 | PubMed |
| Myeloid cell surface antigen CD33 levels (CD33.3166.92.1) | T | OR 0.94 | 9E-445 | PubMed |
| Myeloid cell surface antigen CD33 levels | T | OR 1.02 | 1E-430 | PubMed |
| Myeloid cell surface antigen CD33 levels | T | OR 1.23 | 1E-291 | PubMed |
| Myeloid cell surface antigen CD33 levels | T | OR 1.13 | 3E-165 | PubMed |
| Protein quantitative trait loci | — | — | 2E-77 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | C | β 0.043 | 4E-48 | PubMed |
| Platelet count | T | β 0.026 | 6E-44 | PubMed |
| White blood cell count | T | β 0.027 | 3E-43 | PubMed |
| White blood cell count | T | — | 4E-42 | PubMed |
| Platelet crit (UKB data field 30090) | T | β 0.023 | 1E-35 | PubMed |
| platelet count (mean, inv-norm transformed) | C | β 0.037 | 5E-35 | PubMed |
| white blood cell count (WBC, minimum, inv-norm transformed) | C | β 0.036 | 5E-35 | PubMed |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | T | β 0.023 | 2E-34 | PubMed |
| White blood cell count | T | β 0.02 | 2E-33 | PubMed |
| Lymphocyte count | T | β 0.024 | 8E-33 | PubMed |
| White blood cell count | — | — | 1E-32 | PubMed |
| Protein p13 MTCP-1 protein levels (SomaScan ID:3166-92) | T | OR 1.15 | 1E-31 | PubMed |
| Lymphocyte count | T | — | 4E-30 | PubMed |
| Platelet count (UKB data field 30080) | T | β 0.021 | 6E-30 | PubMed |
Sources
- dbSNP: rs12459419 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies