Genetic variant
rs12413578
rs12413578 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12413578 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
One of 42 more SNPs associated with rheumatoid arthritis based on a meta-analysis of 30,000 patients...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12413578, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12413578
- Position
- chr10:9007290
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Asthma | C | OR 1.17 | 9E-47 | PubMed |
| Asthma | C | OR 1.16 | 8E-41 | PubMed |
| Asthma (childhood onset) | — | OR 1.18 | 9E-41 | PubMed |
| Allergic disease (asthma, hay fever or eczema) | C | OR 1.1 | 1E-27 | PubMed |
| Nonatopic asthma | — | — | 1E-27 | PubMed |
| Asthma (adult onset) | — | — | 5E-26 | PubMed |
| Asthma | — | OR 0.85 | 1E-24 | PubMed |
| Atopic asthma | — | — | 3E-23 | PubMed |
| Asthma (childhood onset) | — | — | 4E-21 | PubMed |
| Medication use (glucocorticoids) | T | OR 0.17 | 5E-21 | PubMed |
| Eosinophil count | T | β 0.033 | 3E-17 | PubMed |
| Eosinophil percentage of white cells | T | β 0.033 | 1E-16 | PubMed |
| Asthma | — | — | 1E-15 | PubMed |
| Eosinophil count | T | β 0.047 | 8E-13 | PubMed |
| Asthma | — | OR 1.12 | 8E-12 | PubMed |
| Lung function (FEV1/FVC) | T | OR 6.6 | 4E-11 | PubMed |
| FEV1/FVC ratio | — | — | 6E-11 | PubMed |
| Allergic disease (asthma, hay fever or eczema) | — | OR 1.11 | 5E-10 | PubMed |
| Forced expiratory volume in 1 second (FEV1) | — | — | 4E-9 | PubMed |
| Rheumatoid arthritis | C | OR 1.2 | 5E-8 | PubMed |
Sources
- dbSNP: rs12413578 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies