Genetic variant
rs12133641
rs12133641 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12133641 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12133641, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12133641
- Position
- chr1:154455807
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| High-sensitivity C-reactive protein levels | G | β 0.084 | 2E-73 | PubMed |
| IL6RA levels | — | OR 0.59 | 3E-73 | PubMed |
| monocyte (fraction, mean, inv-norm transformed) | A | β 0.054 | 1E-64 | PubMed |
| C-reactive protein levels | G | OR 0.12 | 4E-47 | PubMed |
| Atopic dermatitis | G | OR 1.04 | 3E-45 | PubMed |
| monocyte (fraction, maximum, inv-norm transformed) | A | β 0.042 | 1E-43 | PubMed |
| monocyte (fraction, minimum, inv-norm transformed) | A | β 0.035 | 4E-30 | PubMed |
| Glycoprotein acetyls levels | G | β 0.02 | 1E-24 | PubMed |
| C-reactive protein levels | G | β 0.089 | 1E-19 | PubMed |
| C-reactive protein | G | β 0.04 | 4E-17 | PubMed |
| Phospholipids to Total Lipids in Small LDL percentage | G | β 0.02 | 5E-17 | PubMed |
| Red cell distribution width | A | — | 1E-16 | PubMed |
| Cholesteryl Esters to Total Lipids in Small LDL percentage | G | β 0.02 | 3E-15 | PubMed |
| C-reactive protein levels | — | β 0.041 | 2E-14 | PubMed |
| Abdominal aortic aneurysm | A | OR 1.14 | 5E-13 | PubMed |
| LRIG1 protein levels | G | β 0.032 | 1E-12 | PubMed |
| Coronary artery disease | A | β 0.043 | 3E-11 | PubMed |
| mean platelet volume (MPV, minimum, inv-norm transformed) | A | β 0.021 | 3E-11 | PubMed |
| Angina pectoris | G | β 0.051 | 3E-10 | PubMed |
| Abdominal aortic aneurysm | G | β 0.099 | 6E-9 | PubMed |
Sources
- dbSNP: rs12133641 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies