Genetic variant
rs12075
rs12075 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs12075 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs12075, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs12075
- Position
- chr1:159205564
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| CCL13 protein levels | A | OR 0.19 | 2E-300 | PubMed |
| CCL8 protein levels | A | OR 0.17 | 3E-293 | PubMed |
| Serum levels of protein CDSN | G | OR 0.56 | 4E-225 | PubMed |
| CCL26 protein levels | A | OR 0.18 | 4E-217 | PubMed |
| Monocyte chemoattractant protein-1 levels | — | OR 0.69 | 8E-183 | PubMed |
| Serum levels of protein CCL2 | G | OR 0.49 | 3E-168 | PubMed |
| Serum levels of protein CCL11 | G | OR 0.49 | 3E-166 | PubMed |
| Monocyte chemoattractant protein-1 levels | A | OR 0.23 | 7E-149 | PubMed |
| Serum levels of protein CXCL8 | G | OR 0.44 | 8E-140 | PubMed |
| Monocyte chemoattractant protein-1 levels | A | OR 0.12 | 1E-134 | PubMed |
| C-X-C motif chemokine 1 levels | — | OR 0.56 | 2E-107 | PubMed |
| CXCL8 protein levels | A | OR 0.12 | 8E-103 | PubMed |
| Serum levels of protein CXCL6 | G | OR 0.38 | 3E-102 | PubMed |
| Growth-regulated protein alpha levels | G | OR 0.38 | 1E-55 | PubMed |
| Serum levels of protein CCL14 | G | OR 0.27 | 7E-52 | PubMed |
| Inflammatory biomarkers | A | — | 4E-51 | PubMed |
| Monocyte count | A | β 0.027 | 2E-46 | PubMed |
| Monocyte chemoattractant protein-1 levels | G | OR 0.22 | 1E-44 | PubMed |
| Monocyte count | G | β 0.031 | 5E-43 | PubMed |
| Basophil count | A | β 0.031 | 1E-42 | PubMed |
Sources
- dbSNP: rs12075 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies