Genetic variant
rs11902417
rs11902417 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11902417 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11902417, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11902417
- Position
- chr2:20976028
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Total lipid levels in small VLDL | G | OR 0.12 | 9E-141 | PubMed |
| Concentration of small VLDL particles (UKB data field 23509) | A | OR 0.13 | 1E-119 | PubMed |
| Total lipids in small VLDL (UKB data field 23510) | A | OR 0.13 | 6E-114 | PubMed |
| Total lipid levels in medium VLDL | G | OR 0.11 | 6E-112 | PubMed |
| Free cholesterol levels in VLDL | G | OR 0.11 | 2E-110 | PubMed |
| Total lipids in medium VLDL (UKB data field 23503) | A | OR 0.11 | 1E-91 | PubMed |
| Free cholesterol in VLDL (UKB data field 23420) | A | OR 0.11 | 7E-91 | PubMed |
| Triglycerides to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | A | β 0.055 | 5E-60 | PubMed |
| Concentration of large LDL particles | G | β 0.073 | 7E-51 | PubMed |
| Total lipid levels in small LDL | G | β 0.064 | 5E-39 | PubMed |
| Cholesteryl ester levels in LDL | G | β 0.052 | 3E-26 | PubMed |
| Total cholesterol minus HDL-C levels | G | β 0.051 | 7E-26 | PubMed |
| Cholesterol to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | A | β 0.035 | 2E-25 | PubMed |
| Phospholipid levels in medium LDL | G | β 0.05 | 4E-24 | PubMed |
| Free cholesterol levels in very large HDL | G | β 0.036 | 8E-15 | PubMed |
| High density lipoprotein cholesterol levels | A | β 0.052 | 8E-13 | PubMed |
| Ceramide_42:2_[M-H]1- levels | A | β 0.081 | 4E-12 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 0.8 | 9E-10 | PubMed |
| Oxidized LDL cholesterol levels | — | — | 4E-9 | PubMed |
| Triglyceride levels | — | β 0.026 | 5E-8 | PubMed |
Sources
- dbSNP: rs11902417 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies