Genetic variant
rs1171614
rs1171614 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1171614 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1171614, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1171614
- Position
- chr10:59709780
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Carnitine levels | T | OR 0.45 | 2E-309 | PubMed |
| Urate levels (UKB data field 30880) | C | β 0.052 | 5E-161 | PubMed |
| Urate levels | T | β 0.056 | 1E-141 | PubMed |
| Serum uric acid levels | C | β 0.056 | 2E-120 | PubMed |
| Gout | T | OR 0.87 | 2E-90 | PubMed |
| Gout | T | OR 0.89 | 1E-88 | PubMed |
| Carnitine levels | T | OR 0.1 | 2E-81 | PubMed |
| Gout (PheCode 274.1) | T | OR 0.13 | 6E-55 | PubMed |
| Gout and other crystal arthrop (PheCode 274) | T | OR 0.13 | 8E-54 | PubMed |
| X-11381 levels | T | OR 0.18 | 5E-50 | PubMed |
| Deoxycarnitine levels | T | OR 0.17 | 7E-46 | PubMed |
| Height | T | β 0.032 | 4E-42 | PubMed |
| Height | — | — | 3E-40 | PubMed |
| Standing height (UKB data field 50) | C | β 0.016 | 1E-39 | PubMed |
| X-12798 levels | C | OR 0.35 | 4E-39 | PubMed |
| Propionylcarnitine (c3) levels | C | OR 0.33 | 4E-38 | PubMed |
| N-acetylarginine levels | T | OR 0.15 | 4E-35 | PubMed |
| Height | — | β 0.025 | 1E-34 | PubMed |
| Height (baseline) | T | β 0.018 | 7E-34 | PubMed |
| Metabolite levels (acetylcarnitine; acetylcarnitine (C2); C2 carnitine; C2_carnitine) | C | OR 0.19 | 3E-29 | PubMed |
Sources
- dbSNP: rs1171614 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies