Genetic variant
rs117026326
rs117026326 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs117026326 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjö
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs117026326, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs117026326
- Position
- chr7:74711703
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Systemic lupus erythematosus | T | OR 2.14 | 2E-298 | PubMed |
| Systemic lupus erythematosus (PheCode 695.42) | — | — | 1E-54 | PubMed |
| Sjögren's syndrome | T | OR 2.2 | 1E-53 | PubMed |
| Lupus (localized and systemic) (PheCode 695.4) | — | — | 3E-51 | PubMed |
| Diffuse diseases of connective tissue (PheCode 709) | — | — | 4E-29 | PubMed |
| Erythematous conditions (PheCode 695) | — | — | 4E-25 | PubMed |
| Sicca syndrome (PheCode 709.2) | — | — | 2E-22 | PubMed |
| High density lipoprotein cholesterol levels | — | — | 1E-16 | PubMed |
| Sjögren's syndrome | T | OR 1.98 | 1E-15 | PubMed |
| Nephritis and nephropathy in diseases classified elsewhere (PheCode 580.31) | — | — | 3E-14 | PubMed |
| Crohn's disease | — | OR 0.27 | 9E-12 | PubMed |
| Inflammatory bowel disease | — | OR 0.18 | 2E-11 | PubMed |
| Crohn's disease | — | OR 1.37 | 9E-11 | PubMed |
| Systemic lupus erythematosus | T | OR 1.91 | 1E-8 | PubMed |
Sources
- dbSNP: rs117026326 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies