Genetic variant
rs11558471
rs11558471 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11558471 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11558471, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11558471
- Position
- chr8:117173494
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Hemoglobin A1c (HbA1c, mean, inv-norm transformed) | A | β 0.075 | 1E-131 | PubMed |
| Hemoglobin A1c (HbA1c, maximum, inv-norm transformed) | A | β 0.071 | 2E-123 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | A | β 0.061 | 6E-113 | PubMed |
| Type 2 diabetes | G | OR 0.1 | 4E-98 | PubMed |
| Type 2 diabetes (PheCode 250.2) | A | β 0.081 | 4E-87 | PubMed |
| Diabetes mellitus (PheCode 250) | A | β 0.08 | 7E-85 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | A | β 0.054 | 3E-70 | PubMed |
| Diabetes / "Sugar" | A | β 0.089 | 7E-56 | PubMed |
| Takes medication for Diabetes/sugar? | A | β 0.081 | 3E-40 | PubMed |
| Fasting glucose | A | β 0.027 | 5E-35 | PubMed |
| Type 2 diabetes with neurological manifestations (PheCode 250.24) | A | β 0.075 | 2E-33 | PubMed |
| Glycated hemoglobin levels | A | β 0.015 | 3E-25 | PubMed |
| Fasting glucose | A | β 0.032 | 1E-24 | PubMed |
| Fasting blood glucose | G | β 0.035 | 5E-24 | PubMed |
| Fasting blood glucose (BMI interaction) | A | β 0 | 3E-20 | PubMed |
| Glycated hemoglobin levels | A | β 0.015 | 1E-19 | PubMed |
| Proinsulin levels | A | — | 3E-18 | PubMed |
| Tyrosine levels | G | β 0.02 | 3E-18 | PubMed |
| Fasting blood glucose | A | β 0.03 | 7E-18 | PubMed |
| Valine levels | G | β 0.02 | 7E-17 | PubMed |
Sources
- dbSNP: rs11558471 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies