Genetic variant

rs1154988

rs1154988 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1154988 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1154988, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs1154988
Position
chr3:136206349

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Total bilirubin levels A β 0.058 4E-160 PubMed
Total bilirubin levels A β 0.046 3E-82 PubMed
Triglycerides to Total Lipids in Large LDL percentage A β 0.04 1E-74 PubMed
Triglycerides to Total Lipids in IDL percentage A β 0.04 2E-72 PubMed
Cholesteryl Esters to Total Lipids in Small HDL percentage A β 0.04 6E-71 PubMed
Triglycerides to Total Lipids in Medium LDL percentage A β 0.04 1E-63 PubMed
Cholesteryl Esters to Total Lipids in Very Large HDL percentage A β 0.04 2E-59 PubMed
Cholesterol to Total Lipids in Large LDL percentage A β 0.03 1E-50 PubMed
Cholesteryl Esters in Medium HDL A β 0.03 1E-33 PubMed
Alanine levels A β 0.03 1E-32 PubMed
High density lipoprotein cholesterol levels A β 0.026 2E-32 PubMed
Cholesterol in Medium HDL A β 0.02 8E-30 PubMed
Phospholipids to total lipids in very small VLDL percentage (UKB data field 23604) T β 0.053 2E-21 PubMed
Phospholipids to total lipids in IDL percentage (UKB data field 23609) T β 0.053 1E-20 PubMed
Cholesteryl esters to total lipids in medium HDL percentage (UKB data field 23641) T β 0.049 6E-19 PubMed
LEPR protein levels A β 0.057 1E-18 PubMed
Cardiovascular disease — — 1E-18 PubMed
Cholesteryl esters to total lipids in small HDL percentage (UKB data field 23646) T β 0.046 6E-17 PubMed
Triglycerides in very large HDL (UKB data field 23557) T β 0.046 1E-16 PubMed
Fibrinogen A β 0.01 1E-16 PubMed

Sources