RS1142345 Unknown gene
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What This Variant Does
"rs1142345 is a SNP in the TPMT gene, potentially encoding a variant incapable of detoxifying byprodu...
Medication Interactions
Azathioprine toxicity
strong
TPMT*3C — reduced thiopurine metabolism, toxicity risk
Mercaptopurine toxicity
strong
TPMT*3C — dose reduction needed
GWAS Studies (4)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines | — | OR: 7.69 | 9E-61 | PubMed |
| Liver thiopurine methyltransferase levels | — | — | 4E-16 | PubMed |
| DNA methylation PhenoAge acceleration | T | OR: 1.96 | 1E-12 | PubMed |
| Elevated alanine aminotransferase and aspartate aminotransferase levels in acute lymphoblastic leukemia | C | β: 0.44 | 2E-6 | PubMed |