Genetic variant
rs1126605
rs1126605 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1126605 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Polymorphisms in complement system genes and risk of non-Hodgkin lymphoma.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1126605, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1126605
- Position
- chr12:7089608
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 4 levels | T | OR 0.73 | 1E-209 | PubMed |
| Serum levels of protein SCGB1A1 | T | OR 0.69 | 4E-129 | PubMed |
| Catechol O-methyltransferase levels | T | OR 0.54 | 6E-112 | PubMed |
| Protocadherin-12 level in Chronic kidney disease with hypertension and no diabetes (21704_8) | T | OR 1.43 | 2E-98 | PubMed |
| ZW10 interactor levels | T | OR 0.84 | 3E-77 | PubMed |
| NF-kappa-B inhibitor delta levels | T | OR 0.4 | 6E-67 | PubMed |
| Ubiquitin-conjugating enzyme E2 D3 levels | T | OR 0.36 | 2E-55 | PubMed |
| Microfibrillar-associated protein 2 levels | T | OR 0.36 | 6E-52 | PubMed |
| NF-kappa-B inhibitor delta levels | T | OR 0.67 | 4E-47 | PubMed |
| EF-hand domain-containing protein D1 levels | T | OR 0.35 | 3E-46 | PubMed |
| Dynactin subunit 2 levels | T | OR 0.33 | 7E-46 | PubMed |
| Catechol O-methyltransferase levels | T | OR 0.59 | 2E-43 | PubMed |
| ZW10 interactor levels | T | OR 0.33 | 8E-42 | PubMed |
| Clusterin levels | T | OR 0.29 | 2E-36 | PubMed |
| Methylglutaconyl-CoA hydratase, mitochondrial levels | T | OR 0.6 | 1E-35 | PubMed |
| Serum levels of protein SCIN | T | OR 0.36 | 2E-32 | PubMed |
| Catenin alpha-3 protein levels (SomaScan ID:21704-8) | T | OR 1.66 | 5E-26 | PubMed |
| Stomatin-like protein 1 levels | T | OR 0.25 | 7E-26 | PubMed |
| Serum levels of protein B4GALT2 | T | OR 0.34 | 2E-25 | PubMed |
| Myeloid leukemia factor 1 levels | T | OR 0.25 | 5E-25 | PubMed |
Sources
- dbSNP: rs1126605 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies