Genetic variant
rs11209026
rs11209026 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11209026 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A relatively rare allele at SNP rs11209026, in the IL23R gene, appears to provide a fairly strong pr...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11209026, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11209026
- Position
- chr1:67240275
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Inflammatory bowel disease | G | OR 2.01 | 8E-161 | PubMed |
| Crohn's disease | G | OR 2.66 | 1E-64 | PubMed |
| Ulcerative colitis | G | OR 1.74 | 5E-28 | PubMed |
| Ankylosing spondylitis | G | OR 1.62 | 2E-27 | PubMed |
| Crohn's disease | — | OR 3.18 | 4E-21 | PubMed |
| Rheumatoid arthritis or inflammatory bowel disease | — | — | 7E-21 | PubMed |
| Crohn's disease | G | OR 2.2 | 1E-18 | PubMed |
| Crohn's disease | — | OR 2.92 | 2E-18 | PubMed |
| Crohns disease | A | OR 0.86 | 4E-18 | PubMed |
| Ankylosing spondylitis | G | — | 2E-17 | PubMed |
| Interleukin-23 receptor levels | A | OR 0.74 | 3E-16 | PubMed |
| Crohn's disease | G | OR 2.84 | 4E-14 | PubMed |
| Ankylosing spondylitis | — | OR 1.89 | 9E-14 | PubMed |
| Inflammatory bowel disease (Tractor method with European ancestry) | A | β 0.417 | 5E-13 | PubMed |
| Crohn's disease (Tractor method with European ancestry) | A | β 0.329 | 5E-11 | PubMed |
| Inflammatory bowel disease | — | OR 2.56 | 7E-11 | PubMed |
| Inflammatory skin disease | — | — | 2E-10 | PubMed |
| Ulcerative colitis | — | — | 3E-10 | PubMed |
| Ulcerative colitis | — | OR 1.79 | 1E-8 | PubMed |
| Crohn's disease | — | OR 2.56 | 2E-7 | PubMed |
Sources
- dbSNP: rs11209026 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies