Genetic variant
rs11205303
rs11205303 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11205303 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11205303, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11205303
- Position
- chr1:149934520
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Height | T | β 0.044 | 2E-305 | PubMed |
| Height | C | β 0.055 | 1E-300 | PubMed |
| Height | C | β 0.054 | 1E-300 | PubMed |
| What is your height? (cm, inv-normal transformed) | T | OR 0.11 | 2E-251 | PubMed |
| Standing height (UKB data field 50) | C | β 0.032 | 1E-187 | PubMed |
| Height | — | — | 6E-183 | PubMed |
| Height | — | β 0.049 | 1E-168 | PubMed |
| Height (baseline) | T | β 0.035 | 5E-156 | PubMed |
| Height | C | β 0.035 | 1E-137 | PubMed |
| Height | C | β 0.055 | 2E-124 | PubMed |
| Impedance of arm left (UKB data field 23110) | C | β 0.029 | 3E-99 | PubMed |
| Body fat distribution (trunk fat ratio) | C | β 0.053 | 4E-99 | PubMed |
| Impedance of arm right (UKB data field 23109) | C | β 0.028 | 1E-98 | PubMed |
| Body fat distribution (leg fat ratio) | C | β 0.052 | 5E-92 | PubMed |
| Height (maximum, inv-normal transformed) | T | β 0.077 | 5E-85 | PubMed |
| What is your height? (cm, inv-normal transformed) | T | β 0.079 | 4E-70 | PubMed |
| Impedance of whole body (UKB data field 23106) | C | β 0.024 | 3E-62 | PubMed |
| Physical function (baseline) | T | β 0.017 | 6E-56 | PubMed |
| Hip circumference adjusted for BMI | C | β 0.043 | 6E-51 | PubMed |
| Height | C | β 0.038 | 1E-47 | PubMed |
Sources
- dbSNP: rs11205303 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies