Genetic variant
rs11171739
rs11171739 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11171739 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs11171739 has been reported in a large study to be associated with type-1 diabetes. The risk allele...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11171739, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11171739
- Position
- chr12:56076841
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vertex-wise sulcal depth | C | OR 12.04 | 2E-33 | PubMed |
| Autoimmune traits (pleiotropy) | C | — | 2E-20 | PubMed |
| Type 1 diabetes | C | OR 1.23 | 1E-18 | PubMed |
| Brain morphology (MOSTest) | — | — | 2E-17 | PubMed |
| High density lipoprotein cholesterol levels | — | — | 5E-15 | PubMed |
| CAMSIS occupational score | — | β 0.021 | 1E-13 | PubMed |
| Type 1 diabetes | C | OR 1.34 | 1E-11 | PubMed |
| Cortical surface area | T | β 526.55 | 4E-11 | PubMed |
| SIOPS occupational score | — | β 0.018 | 5E-11 | PubMed |
| Self-reported math ability | C | β 0.013 | 1E-10 | PubMed |
| Allergic disease (asthma, hay fever or eczema) | — | OR 1.07 | 4E-10 | PubMed |
| Brain morphology (MOSTest) | — | — | 4E-10 | PubMed |
| Atopic dermatitis | — | OR 0.94 | 6E-10 | PubMed |
| High density lipoprotein cholesterol levels | T | β 0.011 | 9E-10 | PubMed |
| ISEI occupational score | — | β 0.016 | 1E-8 | PubMed |
| Verbal-numerical reasoning | — | — | 3E-8 | PubMed |
| Type 1 diabetes | C | OR 0.71 | 5E-7 | PubMed |
Sources
- dbSNP: rs11171739 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies