Genetic variant
rs11078597
rs11078597 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11078597 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11078597, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11078597
- Position
- chr17:1715069
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| SERPINF2 protein levels | C | OR 0.18 | 2E-135 | PubMed |
| Serum albumin levels | C | β 0.055 | 3E-97 | PubMed |
| Alpha-2-antiplasmin levels | T | OR 0.33 | 2E-86 | PubMed |
| Albumin levels | C | β 0.05 | 2E-79 | PubMed |
| Calcium levels (UKB data field 30680) | C | β 0.049 | 6E-77 | PubMed |
| Sex hormone-binding globulin levels adjusted for BMI and heel estimated bone mineral density | — | — | 3E-64 | PubMed |
| Calcium levels | C | β 0.005 | 3E-64 | PubMed |
| Sex hormone-binding globulin levels adjusted for BMI | C | β 0.017 | 3E-61 | PubMed |
| Sex hormone-binding globulin levels and heel estimated bone mineral density | — | — | 2E-60 | PubMed |
| Calcium levels | C | β 0.045 | 3E-57 | PubMed |
| Sex hormone-binding globulin levels | C | β 0.018 | 8E-55 | PubMed |
| Liver enzyme levels (alkaline phosphatase) | T | β 0.004 | 3E-44 | PubMed |
| Serum alkaline phosphatase levels | C | β 0.034 | 2E-41 | PubMed |
| Total protein levels (UKB data field 30860) | C | β 0.035 | 3E-41 | PubMed |
| Alkaline phosphatase (UKB data field 30610) | C | β 0.029 | 1E-37 | PubMed |
| Serum alkaline phosphatase levels | T | OR 12 | 2E-33 | PubMed |
| Albumin levels | C | OR 0.17 | 6E-28 | PubMed |
| DCBLD2 protein levels | C | β 0.07 | 5E-26 | PubMed |
| Sex hormone-binding globulin levels adjusted for BMI | C | β 0.016 | 1E-25 | PubMed |
| Triglyceride levels | — | — | 8E-24 | PubMed |
Sources
- dbSNP: rs11078597 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies