Genetic variant
rs11075253
rs11075253 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11075253 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11075253, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11075253
- Position
- chr16:15054789
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Cholesteryl ester_20:3_[M+NH4]1+ levels | A | OR 0.16 | 4E-50 | PubMed |
| Phosphatidylcholine_38:2_[M+H]1+/Phosphatidylethanolamine_41:2_[M+H]1+ levels | A | OR 0.23 | 3E-45 | PubMed |
| Cholesterol to Total Lipids in Very Small VLDL percentage | A | β 0.03 | 1E-38 | PubMed |
| Phosphatidylcholine_38:3_[M+H]1+/Phosphatidylethanolamine_41:3_[M+H]1+/Phosphatidate_43:4_[M+NH4]1+ levels | A | OR 0.21 | 2E-38 | PubMed |
| Triglycerides to Total Lipids in Very Small VLDL percentage | A | β 0.03 | 7E-37 | PubMed |
| Phosphatidylcholine(38:3)_[M+OAc]1-/Phosphatidylserine(42:2)_[M-H]1- levels | T | β 0.086 | 1E-31 | PubMed |
| Phosphatidylcholine(38:2)_[M+H]1+/Phosphatidylethanolamine(41:2)_[M+H]1+ levels | C | β 0.086 | 1E-31 | PubMed |
| Phosphatidylcholine(38:3)_[M+H]1+/Phosphatidylethanolamine(41:3)_[M+H]1+/Phosphatidate(43:4)_[M+NH4]1+ levels | C | OR 0.1 | 1E-31 | PubMed |
| Cholesteryl ester(20:3)_[M+NH4]1+ levels | T | OR 0.12 | 1E-31 | PubMed |
| Triglycerides to Total Lipids in IDL percentage | A | β 0.02 | 9E-28 | PubMed |
| Free Cholesterol to Total Lipids in Very Small VLDL percentage | A | β 0.02 | 1E-27 | PubMed |
| Free Cholesterol to Total Lipids in Small VLDL percentage | A | β 0.02 | 1E-25 | PubMed |
| Cholesterol to Total Lipids in Large LDL percentage | A | β 0.02 | 8E-25 | PubMed |
| Phospholipids to Total Lipids in Small VLDL percentage | A | β 0.02 | 5E-23 | PubMed |
| HDL cholesterol | A | β 0.024 | 1E-22 | PubMed |
| Cholesterol to Total Lipids in IDL percentage | A | β 0.02 | 2E-20 | PubMed |
| Triglycerides to Total Lipids in Large LDL percentage | A | β 0.02 | 6E-20 | PubMed |
| Free cholesterol to total lipids ratio in large HDL | C | β 0.037 | 2E-18 | PubMed |
| Total lipids in very large HDL | A | β 0.038 | 2E-17 | PubMed |
| Triglyceride to phosphoglyceride ratio | A | β 0.027 | 3E-17 | PubMed |
Sources
- dbSNP: rs11075253 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies