Genetic variant
rs11067228
rs11067228 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11067228 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11067228, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11067228
- Position
- chr12:114656455
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Prostate-specific antigen levels | A | β 0.038 | 6E-96 | PubMed |
| prostate-specific antigen (PSA, mean, inv-norm transformed) | A | β 0.053 | 3E-62 | PubMed |
| prostate-specific antigen (PSA, maximum, inv-norm transformed) | A | β 0.051 | 6E-60 | PubMed |
| prostate-specific antigen (PSA, mean, inv-norm transformed) | A | β 0.047 | 3E-47 | PubMed |
| prostate-specific antigen (PSA, maximum, inv-norm transformed) | A | β 0.046 | 6E-47 | PubMed |
| Elevated prostate specific antigen [PSA] (PheCode 796) | A | β 0.081 | 3E-40 | PubMed |
| Elevated prostate specific antigen [PSA] (PheCode 796) | A | β 0.074 | 2E-29 | PubMed |
| Heel bone mineral density | — | β 0.017 | 3E-18 | PubMed |
| Heel bone mineral density | A | β 0.016 | 2E-17 | PubMed |
| Heel bone mineral density | — | — | 3E-17 | PubMed |
| Prostate-specific antigen levels | A | β 0.044 | 1E-14 | PubMed |
| Height | G | β 0.018 | 1E-13 | PubMed |
| Prostate cancer | A | OR 1.03 | 1E-11 | PubMed |
| Serum prostate-specific antigen levels | A | OR 8.3 | 2E-11 | PubMed |
| Colorectal cancer | A | β 0.054 | 4E-11 | PubMed |
| Prostate cancer | A | OR 1.04 | 1E-10 | PubMed |
| Hand grip strength (baseline) | A | β 0.008 | 5E-9 | PubMed |
| Heel bone mineral density | A | β 0.027 | 4E-7 | PubMed |
Sources
- dbSNP: rs11067228 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies