RS11066320 Unknown gene
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What This Variant Does
"SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in ..."
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Hypothyroidism | G | OR: 0.14 | 9E-188 | PubMed |
| Medication use (thyroid preparations) | A | OR: 0.17 | 5E-76 | PubMed |
| Systolic blood pressure (MTAG) | A | β: 0.026 | 3E-50 | PubMed |
| Thyroid stimulating hormone levels | G | β: 0.028 | 7E-38 | PubMed |
| Type 1 diabetes | A | OR: 1.2 | 2E-33 | PubMed |
| HDL cholesterol levels | A | β: 0.02 | 2E-24 | PubMed |
| low density lipoprotein cholesterol (LDLC, minimum, inv-norm transformed) | A | β: 0.028 | 3E-23 | PubMed |
| Alanine aminotransferase levels | A | β: 0.004 | 3E-22 | PubMed |
| Right ventricular end diastolic volume | A | — | 1E-18 | PubMed |
| Myocardial infarction | — | OR: 1.07 | 1E-15 | PubMed |
| neutrophil (fraction, mean, inv-norm transformed) | A | β: 0.059 | 8E-14 | PubMed |
| Whole body fat free mass (UKB data field 23101) | G | β: 0.009 | 2E-12 | PubMed |
| Systolic blood pressure | A | OR: 0.25 | 1E-11 | PubMed |
| Right ventricular stroke volume (MTAG) | A | β: 0.044 | 1E-11 | PubMed |
| Right ventricular stroke volume | A | — | 8E-11 | PubMed |
| Polyunsaturated fatty acid levels | A | β: 0.026 | 2E-10 | PubMed |
| Apolipoprotein A1 levels | A | β: 0.013 | 2E-10 | PubMed |
| Free cholesterol levels in large LDL | A | β: 0.025 | 6E-10 | PubMed |
| Phospholipid levels in small LDL | A | β: 0.026 | 9E-10 | PubMed |
| Uterine leiomyoma or breast cancer (pleiotropy) | A | — | 1E-9 | PubMed |