Genetic variant

rs11066301

rs11066301 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11066301 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11066301, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs11066301
Position
chr12:112433568

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Eosinophil count G — 2E-344 PubMed
Cystatin C plasma levels — — 2E-153 PubMed
Cystatin C levels G β 0.054 5E-109 PubMed
Hemoglobin concentration G β 0.046 9E-44 PubMed
Hemoglobin concentration G β 0.049 5E-39 PubMed
Non-albumin protein levels G β 0.033 2E-37 PubMed
Total bilirubin levels G β 0.03 4E-35 PubMed
Urate levels G β 0.027 2E-27 PubMed
Total cholesterol levels G β 0.025 3E-24 PubMed
Glycated hemoglobin levels G β 0.025 8E-24 PubMed
Direct bilirubin levels G β 0.026 3E-23 PubMed
High density lipoprotein cholesterol levels G β 0.023 2E-19 PubMed
Low density lipoprotein cholesterol levels G β 0.021 1E-17 PubMed
Serum phosphate levels G β 0.021 5E-16 PubMed
Serum albumin levels G β 0.021 7E-16 PubMed
Mean arterial pressure G OR 0.42 8E-16 PubMed
Alanine aminotransferase levels G β 0.019 6E-15 PubMed
Medication use (beta blocking agents) G β 0.065 7E-15 PubMed
Serum alkaline phosphatase levels G β 0.018 3E-13 PubMed
Peripheral artery disease G OR 1.06 3E-12 PubMed

Sources