Genetic variant
rs11012732
rs11012732 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs11012732 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs11012732 is a SNP in the MLLT10 gene on ch 10p12.31. A study of ~1,600 patients with meningioma, a...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs11012732, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs11012732
- Position
- chr10:21541175
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Body mass index | A | β 0.029 | 1E-26 | PubMed |
| Body mass index | — | — | 2E-25 | PubMed |
| Body mass index | — | — | 5E-25 | PubMed |
| Body fat percentage | G | β 0.016 | 2E-24 | PubMed |
| Body mass index | A | β 0.021 | 6E-24 | PubMed |
| Body mass index (UKB data field 21001) | G | β 0.019 | 2E-23 | PubMed |
| Albumin levels | A | β 0.026 | 3E-22 | PubMed |
| Metabolic biomarkers (multivariate analysis) | G | — | 1E-21 | PubMed |
| Trunk fat mass (UKB data field 23128) | G | β 0.018 | 5E-21 | PubMed |
| Body mass index | G | β 0.023 | 4E-20 | PubMed |
| Serum albumin levels | G | β 0.023 | 4E-19 | PubMed |
| Arm fat percentage left (UKB data field 23123) | G | β 0.013 | 4E-19 | PubMed |
| Arm fat percentage right (UKB data field 23119) | G | β 0.013 | 5E-19 | PubMed |
| Whole body fat mass (UKB data field 23100) | G | β 0.022 | 5E-19 | PubMed |
| Body mass index | G | β 0.022 | 7E-18 | PubMed |
| Endometriosis (MTAG) | A | β 0.024 | 4E-16 | PubMed |
| Meningioma | A | OR 1.46 | 2E-14 | PubMed |
| C-reactive protein levels (MTAG) | A | β 0.016 | 6E-13 | PubMed |
| C-reactive protein levels | A | β 0.015 | 8E-13 | PubMed |
| Pain intensity (NRS pain scale 0-11) | — | β 0.015 | 8E-13 | PubMed |
Sources
- dbSNP: rs11012732 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies