Genetic variant
rs10889353
rs10889353 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10889353 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-densi...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10889353, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10889353
- Position
- chr1:62652525
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Phospholipid levels in chylomicrons and extremely large VLDL | C | β 0.07 | 4E-260 | PubMed |
| Concentration of chylomicrons and extremely large VLDL particles | C | β 0.07 | 2E-246 | PubMed |
| Total lipid levels in chylomicrons and extremely large VLDL | C | β 0.07 | 4E-230 | PubMed |
| Phospholipids in very small VLDL | C | β 0.05 | 4E-112 | PubMed |
| Phosphatidylinositol(36:2)_[M-H]1- levels | G | OR 0.1 | 4E-32 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | A | β 0.034 | 5E-29 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | A | β 0.034 | 1E-26 | PubMed |
| Triglyceride levels | — | β 0.043 | 5E-24 | PubMed |
| Total cholesterol levels | — | OR 3.36 | 2E-20 | PubMed |
| Linoleic acid to total fatty acids percentage | C | — | 8E-16 | PubMed |
| Lipid metabolism phenotypes | — | OR 2.97 | 1E-14 | PubMed |
| Cholesterol, total | C | β 0.08 | 4E-12 | PubMed |
| Phosphatidylinositol (18:0_20:3) levels | C | OR 0.17 | 4E-11 | PubMed |
| Total cholesterol levels | C | β 0.07 | 2E-10 | PubMed |
| Low density lipoprotein cholesterol levels | — | OR 2.01 | 8E-10 | PubMed |
| Triglycerides | C | OR 0.13 | 2E-9 | PubMed |
| Triacylglyceride levels | C | β 0.07 | 9E-9 | PubMed |
| Triglycerides | C | β 0.05 | 3E-7 | PubMed |
| LDL cholesterol | C | β 0.06 | 8E-6 | PubMed |
Sources
- dbSNP: rs10889353 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies