Genetic variant
rs10876550
rs10876550 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10876550 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10876550, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10876550
- Position
- chr12:54318524
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Platelet count | A | — | 1E-194 | PubMed |
| Platelet count | A | β 0.052 | 2E-177 | PubMed |
| Platelet count (UKB data field 30080) | A | β 0.05 | 7E-174 | PubMed |
| Platelet count | A | β 0.043 | 2E-148 | PubMed |
| Platelet distribution width (UKB data field 30110) | A | β 0.044 | 5E-128 | PubMed |
| Platelet count | A | β 0.046 | 5E-121 | PubMed |
| CCL28 protein levels | A | OR 0.11 | 9E-102 | PubMed |
| Platelet count | G | — | 1E-78 | PubMed |
| Platelet count | A | β 0.058 | 5E-74 | PubMed |
| Mean platelet volume | A | β 0.062 | 3E-57 | PubMed |
| Immature platelet count | A | OR 0.11 | 3E-49 | PubMed |
| RBPMS2 protein levels | A | β 0.066 | 2E-28 | PubMed |
| Blood cell traits latent factor 5 (platelet) | — | — | 2E-25 | PubMed |
| APRT protein levels | A | β 0.061 | 6E-25 | PubMed |
| FADD protein levels | A | β 0.062 | 1E-24 | PubMed |
| CASP8 protein levels | A | β 0.059 | 1E-23 | PubMed |
| LBR protein levels | A | β 0.055 | 2E-21 | PubMed |
| FKBP4 protein levels | A | β 0.057 | 7E-21 | PubMed |
| COMMD1 protein levels | A | β 0.056 | 1E-20 | PubMed |
| DNMBP protein levels | A | β 0.055 | 4E-20 | PubMed |
Sources
- dbSNP: rs10876550 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies