Genetic variant
rs10838681
rs10838681 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10838681 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10838681, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10838681
- Position
- chr11:47253513
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Free Cholesterol to Total Lipids in Medium LDL percentage | A | β 0.03 | 2E-43 | PubMed |
| Free Cholesterol to Total Lipids in Large LDL percentage | A | β 0.03 | 3E-34 | PubMed |
| Triglyceride levels (UKB data field 30870) | A | β 0.025 | 3E-33 | PubMed |
| Cholesterol to Total Lipids in Small HDL percentage | A | β 0.03 | 7E-33 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | A | β 0.03 | 5E-31 | PubMed |
| Phospholipid levels in chylomicrons and extremely large VLDL | A | β 0.02 | 3E-28 | PubMed |
| Triglyceride levels in non-type 2 diabetes | — | — | 7E-28 | PubMed |
| Triglycerides in medium HDL | A | β 0.02 | 1E-26 | PubMed |
| Cholesterol levels in chylomicrons and extremely large VLDL | A | β 0.02 | 1E-26 | PubMed |
| Free cholesterol levels in chylomicrons and extremely large VLDL | A | β 0.02 | 3E-26 | PubMed |
| Cholesteryl ester levels in chylomicrons and extremely large VLDL | A | β 0.02 | 5E-26 | PubMed |
| Concentration of chylomicrons and extremely large VLDL particles | A | β 0.02 | 2E-25 | PubMed |
| Triglyceride levels (MTAG) | A | β 0.029 | 5E-25 | PubMed |
| Average diameter for VLDL particles | A | β 0.02 | 2E-24 | PubMed |
| Triglycerides in HDL | A | β 0.02 | 9E-24 | PubMed |
| Cholesteryl Esters to Total Lipids in Very Small VLDL percentage | A | β 0.02 | 1E-22 | PubMed |
| Triglycerides | A | β 0.022 | 2E-22 | PubMed |
| Triglycerides in very small VLDL | A | β 0.02 | 3E-22 | PubMed |
| Total lipid levels in chylomicrons and extremely large VLDL | A | β 0.02 | 6E-22 | PubMed |
| Triglycerides in small VLDL | A | β 0.02 | 3E-21 | PubMed |
Sources
- dbSNP: rs10838681 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies