Genetic variant
rs1077834
rs1077834 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1077834 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1077834, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1077834
- Position
- chr15:58431280
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides in large LDL | T | OR 0.28 | 8E-769 | PubMed |
| Triglycerides in IDL | T | OR 0.27 | 5E-715 | PubMed |
| Triglyceride levels in LDL | T | OR 0.26 | 2E-675 | PubMed |
| Triglycerides in medium LDL | T | OR 0.25 | 8E-648 | PubMed |
| Triglycerides in very large HDL | T | OR 0.23 | 6E-553 | PubMed |
| Free cholesterol to total lipids ratio in medium VLDL | T | OR 0.21 | 1E-441 | PubMed |
| Triglycerides in small LDL | T | OR 0.19 | 1E-373 | PubMed |
| Cholesteryl esters to total lipids ratio in medium HDL | T | OR 0.18 | 3E-311 | PubMed |
| Phospholipids to total lipids ratio in medium HDL | T | OR 0.17 | 1E-289 | PubMed |
| Triglycerides in very small VLDL | T | OR 0.16 | 6E-253 | PubMed |
| 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels | T | OR 0.41 | 3E-245 | PubMed |
| Total cholesterol levels | C | β 0.065 | 2E-244 | PubMed |
| Concentration of very small VLDL particles | T | OR 0.15 | 6E-239 | PubMed |
| Total cholesterol to total lipids ratio in chylomicrons and extremely large VLDL | T | OR 0.15 | 2E-234 | PubMed |
| Total lipids in very small VLDL | T | OR 0.15 | 6E-220 | PubMed |
| 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) levels | T | OR 0.37 | 1E-197 | PubMed |
| Triglycerides to total lipids ratio in large HDL | T | OR 0.14 | 2E-190 | PubMed |
| Cholesteryl esters to total lipids ratio in large VLDL | T | OR 0.14 | 2E-187 | PubMed |
| Total cholesterol to total lipids ratio in medium HDL | T | OR 0.13 | 7E-174 | PubMed |
| Phospholipids to total lipids ratio in large LDL | T | OR 0.13 | 9E-171 | PubMed |
Sources
- dbSNP: rs1077834 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies