Genetic variant
rs10774624
rs10774624 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10774624 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
One of 42 more SNPs associated with rheumatoid arthritis based on a meta-analysis of 30,000 patients...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10774624, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10774624
- Position
- chr12:111395984
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| platelet count (mean, inv-norm transformed) | G | OR 0.12 | 1E-323 | PubMed |
| eosinophil (absolute count, mean, inv-norm transformed) | G | OR 0.13 | 1E-323 | PubMed |
| Eosinophil count | — | — | 1E-300 | PubMed |
| KLRK1 protein levels | A | β 0.071 | 1E-39 | PubMed |
| KIR2DL2 protein levels | A | β 0.058 | 1E-32 | PubMed |
| Kynurenine levels | A | OR 0.11 | 1E-27 | PubMed |
| HNRNPUL1 protein levels | A | β 0.059 | 1E-23 | PubMed |
| Vitiligo | G | OR 1.27 | 6E-23 | PubMed |
| UBE2L6 protein levels | A | β 0.058 | 8E-23 | PubMed |
| eosinophil (absolute count, minimum, inv-norm transformed) | G | β 0.068 | 1E-19 | PubMed |
| TYMP protein levels | A | β 0.053 | 2E-19 | PubMed |
| Systolic blood pressure | G | OR 0.48 | 3E-19 | PubMed |
| C-X-C motif chemokine 16 levels | A | β 0.072 | 6E-19 | PubMed |
| Interleukin-27 levels | A | β 0.074 | 8E-19 | PubMed |
| Atherosclerosis of the extremities (PheCode 440.2) | G | β 0.099 | 2E-17 | PubMed |
| Total cholesterol levels in HDL | A | β 0.033 | 2E-15 | PubMed |
| NAGK protein levels | A | β 0.045 | 6E-15 | PubMed |
| HMCN2 protein levels | A | β 0.039 | 7E-15 | PubMed |
| JAM2 protein levels | A | β 0.04 | 2E-14 | PubMed |
| Heart failure | G | β 0.034 | 2E-14 | PubMed |
Sources
- dbSNP: rs10774624 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies