Genetic variant
rs10761741
rs10761741 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10761741 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Vascular Endothelial Growth Factor and Ischemic Heart Disease Risk: A Mendelian Randomization Study.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10761741, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10761741
- Position
- chr10:63306426
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean platelet volume | T | OR 0.13 | 5E-287 | PubMed |
| HBEGF protein levels | T | OR 0.15 | 8E-182 | PubMed |
| Immature platelet fraction | T | OR 0.18 | 1E-133 | PubMed |
| High fluorescence immature platelet fraction | T | OR 0.18 | 7E-131 | PubMed |
| DKK1 protein levels | T | OR 0.13 | 2E-124 | PubMed |
| Immature platelet count | T | OR 0.17 | 2E-118 | PubMed |
| Platelet large cell ratio | T | OR 0.15 | 8E-101 | PubMed |
| Platelet side fluorescence | T | OR 0.17 | 4E-98 | PubMed |
| Platelet count | T | β 0.077 | 3E-96 | PubMed |
| PF4 protein levels | T | OR 0.1 | 2E-70 | PubMed |
| APP protein levels | T | β 0.094 | 2E-64 | PubMed |
| Blood cell traits latent factor 5 (platelet) | — | — | 2E-61 | PubMed |
| TIMP3 protein levels | T | β 0.075 | 2E-54 | PubMed |
| SORT1 protein levels | T | β 0.08 | 3E-48 | PubMed |
| TNFSF12 protein levels | T | β 0.069 | 3E-47 | PubMed |
| Proheparin-binding EGF-like growth factor levels | T | OR 0.11 | 3E-41 | PubMed |
| CST7 protein levels | T | β 0.047 | 8E-38 | PubMed |
| MPIG6B protein levels | T | β 0.07 | 4E-32 | PubMed |
| CD40 protein levels | T | β 0.061 | 2E-29 | PubMed |
| Proteinase-activated receptor 1 levels | T | β 0.084 | 6E-24 | PubMed |
Sources
- dbSNP: rs10761741 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies