Genetic variant
rs1042779
rs1042779 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1042779 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. P...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1042779, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1042779
- Position
- chr3:52786995
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Single Ig IL-1-related receptor levels | A | OR 0.94 | 3E-1748 | PubMed |
| Janus kinase and microtubule-interacting protein 3 levels | A | OR 0.6 | 2E-500 | PubMed |
| Single Ig IL-1-related receptor levels (SIGIRR.8326.63.3) | G | OR 0.81 | 2E-312 | PubMed |
| Janus kinase and microtubule-interacting protein 3 levels (JAKMIP3.9068.17.3) | G | OR 0.79 | 3E-285 | PubMed |
| Inter-alpha-trypsin inhibitor heavy chain H1 levels (ITIH1.7955.195.3) | G | OR 0.65 | 2E-171 | PubMed |
| Ubiquitin-conjugating enzyme E2 Q1 level in Chronic kidney disease with hypertension and no diabetes (21732_78) | G | OR 0.89 | 1E-73 | PubMed |
| Protein FAM110A protein levels (SomaScan ID:25073-13) | G | OR 1.13 | 1E-44 | PubMed |
| E3 ubiquitin-protein ligase RNF146 levels | A | OR 0.18 | 3E-40 | PubMed |
| NudC domain-containing protein 3 protein levels (SomaScan ID:8326-63) | G | OR 0.97 | 1E-31 | PubMed |
| Single Ig IL-1-related receptor level in Chronic kidney disease with hypertension and no diabetes (8326_63) | G | OR 0.65 | 5E-31 | PubMed |
| Sodium channel subunit beta-2 levels | A | OR 0.11 | 5E-17 | PubMed |
| Inter-alpha-trypsin inhibitor heavy chain H1 level in Chronic kidney disease with hypertension and no diabetes (7955_195) | G | OR 0.48 | 2E-15 | PubMed |
| Zinc finger protein 334 levels | A | β 0.099 | 7E-14 | PubMed |
| Ubiquitin conjugation factor E4 A levels | G | OR 0.19 | 3E-13 | PubMed |
| Bipolar disorder | A | OR 1.19 | 2E-7 | PubMed |
| Verbal learning | G | OR 5.17 | 2E-7 | PubMed |
Sources
- dbSNP: rs1042779 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies