Genetic variant
rs1042034
rs1042034 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1042034 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1042034, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1042034
- Position
- chr2:21002409
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| High-density lipoprotein levels | T | β 0.036 | 4E-80 | PubMed |
| Triglycerides | C | β 0.081 | 1E-72 | PubMed |
| Triglycerides to total lipids ratio in very small VLDL | T | β 0.08 | 7E-69 | PubMed |
| Total cholesterol to total lipids ratio in very small VLDL | T | β 0.075 | 1E-59 | PubMed |
| High density lipoprotein cholesterol levels | C | β 0.066 | 5E-58 | PubMed |
| Cholesteryl esters to total lipids ratio in very small VLDL | T | β 0.071 | 3E-55 | PubMed |
| Metabolic dysfunction-associated steatotic liver disease (MTAG) | C | β 0.078 | 6E-54 | PubMed |
| Triglycerides to total lipids ratio in very large HDL | T | β 0.07 | 1E-51 | PubMed |
| Triglycerides | C | OR 5.99 | 1E-45 | PubMed |
| Phospholipids in very large HDL | T | β 0.045 | 2E-43 | PubMed |
| Triglycerides to total lipids ratio in small HDL | T | β 0.062 | 1E-42 | PubMed |
| Triglycerides in medium HDL | T | β 0.061 | 3E-40 | PubMed |
| Triglycerides in small HDL | T | β 0.058 | 6E-36 | PubMed |
| Free cholesterol to total lipids ratio in medium VLDL | T | β 0.056 | 5E-35 | PubMed |
| Concentration of very large HDL particles | T | β 0.039 | 1E-32 | PubMed |
| HDL cholesterol | C | OR 0.9 | 1E-30 | PubMed |
| Ratio of monounsaturated fatty acids to total fatty acids | T | β 0.05 | 1E-27 | PubMed |
| Docosahexaenoic acid levels | C | — | 1E-26 | PubMed |
| Polyunsaturated fatty acid levels | C | — | 1E-26 | PubMed |
| Docosahexaenoic acid to total fatty acids percentage | C | — | 1E-24 | PubMed |
Sources
- dbSNP: rs1042034 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies