Genetic variant
rs10149470
rs10149470 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10149470 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Biological annotation of genetic loci associated with intelligence in ameta-analysis of 87,740 individuals
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10149470, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10149470
- Position
- chr14:103551616
Genome-wide association studies (13)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Depression | G | OR 1.02 | 7E-22 | PubMed |
| Attention deficit hyperactivity disorder or autism spectrum disorder or intelligence (pleiotropy) | — | — | 2E-16 | PubMed |
| Depression | — | β 0 | 2E-16 | PubMed |
| Depression | A | β 0.024 | 2E-16 | PubMed |
| Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) | — | — | 5E-13 | PubMed |
| Intelligence (MTAG) | A | β 0.02 | 5E-11 | PubMed |
| Bipolar disorder or major depressive disorder | G | OR 1.03 | 1E-10 | PubMed |
| Cognitive ability (MTAG) | — | OR 5.98 | 2E-9 | PubMed |
| Cognitive ability | — | OR 5.95 | 3E-9 | PubMed |
| Depression | G | OR 1.03 | 3E-9 | PubMed |
| Perisylvian thickness | — | β 0.038 | 4E-9 | PubMed |
| Autism and major depressive disorder (MTAG) | A | β 0.049 | 9E-9 | PubMed |
| Extremely high intelligence | A | OR 5.49 | 4E-8 | PubMed |
Sources
- dbSNP: rs10149470 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies