Genetic variant
rs10096633
rs10096633 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs10096633 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs10096633, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs10096633
- Position
- chr8:19973410
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides in IDL | T | OR 0.11 | 2E-303 | PubMed |
| Cholesteryl Esters to Total Lipids in Small HDL percentage | T | OR 0.15 | 2E-238 | PubMed |
| Cholesteryl Esters to Total Lipids in Very Large HDL percentage | T | OR 0.13 | 2E-185 | PubMed |
| Triglycerides in medium VLDL | T | OR 0.18 | 1E-179 | PubMed |
| Cholesteryl Esters to Total Lipids in Small HDL percentage | T | OR 0.12 | 2E-171 | PubMed |
| Mean diameter of VLDL particles | T | OR 0.17 | 3E-163 | PubMed |
| Triglyceride levels in very small VLDL | C | OR 0.16 | 2E-158 | PubMed |
| Cholesteryl Esters in Small VLDL | T | β 0.08 | 1E-151 | PubMed |
| Total lipid levels in small VLDL | C | OR 0.15 | 1E-133 | PubMed |
| Total cholesterol in very large VLDL | T | OR 0.15 | 2E-131 | PubMed |
| Triglycerides in very large VLDL | T | OR 0.15 | 7E-131 | PubMed |
| Total lipids in very large VLDL | T | OR 0.15 | 2E-130 | PubMed |
| Concentration of very large VLDL particles | T | OR 0.15 | 5E-130 | PubMed |
| Non-HDL cholesterol levels | — | — | 7E-121 | PubMed |
| Triglycerides in very small VLDL (UKB data field 23522) | T | OR 0.16 | 1E-119 | PubMed |
| Phospholipids in very large VLDL | T | OR 0.15 | 2E-118 | PubMed |
| Cholesterol in Small VLDL | T | β 0.07 | 6E-117 | PubMed |
| Free cholesterol in very large VLDL | T | OR 0.15 | 1E-116 | PubMed |
| Free cholesterol to total lipids ratio in IDL | T | OR 0.14 | 2E-116 | PubMed |
| Concentration of small VLDL particles (UKB data field 23509) | T | OR 0.16 | 2E-115 | PubMed |
Sources
- dbSNP: rs10096633 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies