Genetic variant
rs99780
rs99780 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs99780 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genetic variants of the FADS1 FADS2 gene cluster are associated with altered (n-6) and (n-3) essenti...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs99780, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs99780
- Position
- chr11:61829161
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Docosahexaenoic acid levels | T | OR 0.33 | 1E-2288 | PubMed |
| Docosahexaenoic acid levels | T | OR 0.28 | 7E-2029 | PubMed |
| 1-margaroyl-2-arachidonoyl-GPC (17:0/20:4) levels | T | OR 0.59 | 4E-327 | PubMed |
| Arachidonate (20:4n6) levels | T | OR 0.38 | 2E-278 | PubMed |
| 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6) levels | T | OR 0.5 | 5E-231 | PubMed |
| 1-arachidonoyl-gpc (20:4n6) levels | T | OR 0.49 | 3E-221 | PubMed |
| 1-pentadecanoyl-2-arachidonoyl-GPC (15:0/20:4) levels | T | OR 0.47 | 2E-205 | PubMed |
| 2-arachidonoyl-GPC (20:4) levels | T | OR 0.41 | 6E-152 | PubMed |
| 1-arachidonylglycerol (20:4) levels | T | OR 0.29 | 2E-134 | PubMed |
| 1-stearoyl-2-meadoyl-GPC (18:0/20:3n9) levels | T | OR 0.28 | 3E-130 | PubMed |
| 1-palmityl-2-arachidonoyl-GPC (o-16:0/20:4) levels | T | OR 0.37 | 5E-125 | PubMed |
| Oleoyl-arachidonoyl-glycerol (18:1/20:4) [2] levels | T | OR 0.33 | 7E-100 | PubMed |
| Saturated fatty acids levels | T | — | 2E-98 | PubMed |
| Phosphatidylcholine (16:0/22:5n3, 18:1/20:4) levels | T | OR 0.32 | 1E-92 | PubMed |
| 1-arachidoyl-2-arachidonoyl-GPC (20:0/20:4) levels | T | OR 0.32 | 2E-91 | PubMed |
| 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) levels | T | OR 0.21 | 4E-88 | PubMed |
| 1-arachidonoyl-GPE (20:4n6) levels | T | OR 0.31 | 2E-87 | PubMed |
| Triglyceride levels | — | β 0.051 | 7E-79 | PubMed |
| 1-palmitoyl-2-eicosapentaenoyl-GPC (16:0/20:5) levels | T | OR 0.28 | 7E-77 | PubMed |
| Phosphatidylcholine (15-MHDA_20:4) levels | T | OR 0.41 | 2E-71 | PubMed |
Sources
- dbSNP: rs99780 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies