Genetic variant
rs9924561
rs9924561 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9924561 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9924561, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9924561
- Position
- chr16:264781
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | — | OR 1.54 | 1E-167 | PubMed |
| Mean corpuscular volume | — | OR 3.71 | 3E-142 | PubMed |
| Mean corpuscular hemoglobin | — | OR 1.48 | 8E-125 | PubMed |
| Mean corpuscular volume | — | OR 3.67 | 2E-110 | PubMed |
| Mean corpuscular hemoglobin concentration | — | OR 0.37 | 8E-87 | PubMed |
| Mean corpuscular hemoglobin concentration | — | OR 0.36 | 1E-71 | PubMed |
| Red blood cell count | — | OR 0.16 | 3E-53 | PubMed |
| Hemoglobin levels | T | OR 0.24 | 2E-49 | PubMed |
| Mean corpuscular hemoglobin | — | OR 1.66 | 5E-48 | PubMed |
| Mean corpuscular hemoglobin | T | OR 1.72 | 4E-42 | PubMed |
| Mean corpuscular hemoglobin concentration | — | OR 0.43 | 4E-41 | PubMed |
| Red blood cell count | — | OR 0.16 | 7E-41 | PubMed |
| Mean corpuscular volume | — | OR 3.66 | 2E-34 | PubMed |
| Mean corpuscular volume | T | OR 3.88 | 6E-30 | PubMed |
| Mean corpuscular hemoglobin concentration | — | OR 0.47 | 4E-23 | PubMed |
| Hemoglobin concentration | — | OR 0.2 | 3E-22 | PubMed |
| Red cell distribution width | — | OR 0.27 | 8E-20 | PubMed |
| Hemoglobin concentration | — | OR 0.18 | 3E-18 | PubMed |
| Red blood cell traits | T | OR 0.47 | 9E-17 | PubMed |
| Red blood cell count | — | OR 0.16 | 1E-14 | PubMed |
Sources
- dbSNP: rs9924561 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies