RS9923231 VKORC1

Drug Response Chr 16:31096367 snv intergenic variant

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What This Variant Does

"Several SNPs in the VKORC1 gene have been linked to warfarin sensitivity, with perhaps the most comm...

Associated Conditions

Warfarin response

phenprocoumon response - Toxicity

phenprocoumon response - Dosage

warfarin response - Toxicity

Venous thromboembolism

acenocoumarol response - Dosage

warfarin response - Efficacy

See cases

Thrombus

warfarin response - Dosage

VKORC1-related disorder

Warfarin response

phenprocoumon response - Toxicity

phenprocoumon response - Dosage

Medication Interactions

Warfarin dose_adjustment strong

VKORC1 — affects warfarin sensitivity, key for dosing

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
Warfarin maintenance dose	T	OR: 0.97	3E-181	PubMed
Warfarin maintenance dose	—	—	9E-31	PubMed
Body mass index	T	β: 0.027	5E-28	PubMed

ClinVar Assertions (1)

NM_024006.4(VKORC1):c.-1639G>A

· 15 submitters

Population Frequencies

1kG AFR

94.6%

1kG ALL

35.6%

1kG AMR

58.9%

1kG EAS

11.5%

1kG EUR

61.2%

1kG SAS

85.5%

Other Variants in VKORC1