Genetic variant
rs9815073
rs9815073 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9815073 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9815073, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9815073
- Position
- chr3:188397894
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Interleukin-12 subunit beta levels | A | OR 0.29 | 1E-107 | PubMed |
| Interleukin-23 levels | A | OR 0.28 | 1E-81 | PubMed |
| Interleukin-12 subunit beta levels | A | OR 0.25 | 4E-67 | PubMed |
| Other non-epithelial cancer of skin (PheCode 172.2) | C | OR 0.11 | 6E-46 | PubMed |
| Serum levels of protein IL12B;IL23A | A | OR 0.27 | 4E-42 | PubMed |
| Serum levels of protein IL12B | A | OR 0.22 | 3E-30 | PubMed |
| Interleukin-12 levels | A | OR 0.29 | 8E-30 | PubMed |
| Other non-epithelial cancer of skin (PheCode 172.2) | C | OR 0.1 | 1E-28 | PubMed |
| CDH17 protein levels | A | β 0.05 | 3E-28 | PubMed |
| Interleukin-23 levels | A | OR 0.29 | 8E-24 | PubMed |
| Interleukin-23 levels (IL12B.IL23A.10365.132.3) | A | OR 0.21 | 9E-15 | PubMed |
| Seborrheic keratosis (PheCode 702.2) | C | β 0.047 | 4E-12 | PubMed |
| Chronic lymphocytic leukemia | C | OR 1.18 | 4E-8 | PubMed |
| Mosquito bite size | C | β 0.033 | 4E-8 | PubMed |
Sources
- dbSNP: rs9815073 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies