Genetic variant
rs974819
rs974819 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs974819 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs974819, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs974819
- Position
- chr11:103789839
Genome-wide association studies (13)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Coronary artery disease | T | β 0.067 | 6E-29 | PubMed |
| Coronary artery disease | T | β 0.061 | 1E-28 | PubMed |
| Coronary atherosclerosis (PheCode 411.4) | T | β 0.048 | 2E-17 | PubMed |
| Takes medication for coronary artery/ coronary heart disease? | T | β 0.066 | 1E-15 | PubMed |
| Coronary artery / coronary heart disease (including heart attack, angina) | T | β 0.062 | 3E-15 | PubMed |
| Other chronic ischemic heart disease, unspecified (PheCode 411.8) | T | β 0.055 | 9E-15 | PubMed |
| Carotid intima-media thickness (MTAG) | T | β 0.03 | 1E-10 | PubMed |
| Migraine and/or pulse pressure | — | — | 2E-10 | PubMed |
| Coronary heart disease | T | OR 1.07 | 2E-9 | PubMed |
| Pulse pressure | T | β 0.094 | 1E-8 | PubMed |
| Pulse pressure | T | OR 0.11 | 2E-8 | PubMed |
| Pulse pressure | C | β 0.011 | 2E-8 | PubMed |
| Pulse pressure | C | β 0.097 | 3E-7 | PubMed |
Sources
- dbSNP: rs974819 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies