Genetic variant

rs9686661

rs9686661 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9686661 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9686661, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs9686661
Position
chr5:56565959

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phospholipids to Total Lipids in Small LDL percentage T β 0.041 5E-32 PubMed
Cholesteryl Esters to Total Lipids in Small LDL percentage T β 0.036 7E-25 PubMed
Phospholipids to Total Lipids in Chylomicrons and Extremely Large VLDL percentage T β 0.034 7E-22 PubMed
Total cholesterol in medium VLDL T β 0.049 3E-21 PubMed
Free cholesterol in chylomicrons and extremely large VLDL (UKB data field 23486) T β 0.053 2E-20 PubMed
Impedance of arm right (UKB data field 23109) T β 0.015 2E-20 PubMed
Cholesteryl esters to total lipids ratio in very large VLDL C β 0.045 2E-20 PubMed
Body fat percentage and triglycerides (pairwise) C — 2E-20 PubMed
Monounsaturated fatty acid levels T — 3E-20 PubMed
Triglycerides C β 0.043 5E-20 PubMed
Monounsaturated fatty acid levels T — 1E-19 PubMed
Triglycerides to total lipids in large HDL percentage (UKB data field 23638) T β 0.05 3E-19 PubMed
Ratio of triglycerides to phosphoglycerides T β 0.047 5E-19 PubMed
Triglycerides in very small VLDL (UKB data field 23522) T β 0.051 8E-19 PubMed
Total cholesterol in very large VLDL T β 0.046 8E-19 PubMed
Triglycerides in chylomicrons and extremely large VLDL (UKB data field 23487) T β 0.05 2E-18 PubMed
Reticulocyte percentage (UKB data field 30240) T β 0.02 7E-18 PubMed
Free cholesterol in very large VLDL T β 0.045 1E-17 PubMed
Phospholipid levels in chylomicrons and extremely large VLDL T β 0.044 1E-17 PubMed
Total cholesterol levels in VLDL T β 0.044 1E-17 PubMed

Sources