Genetic variant
rs9533090
rs9533090 is a single-letter difference in human DNA, on chromosome 13. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9533090 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9533090, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9533090
- Position
- chr13:42377313
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lumbar spine bone mineral density | T | β 0.1 | 5E-68 | PubMed |
| DXA-Bone mineral density (lumbar spine) | T | OR 0.14 | 1E-62 | PubMed |
| DXA-Bone mineral density (spine) (UKB data field 23234) | T | OR 0.13 | 9E-61 | PubMed |
| DXA-Bone mineral density (trunk) (UKB data field 23241) | T | OR 0.12 | 7E-49 | PubMed |
| DXA-Bone mineral density (ribs) (UKB data field 23233) | T | OR 0.1 | 2E-35 | PubMed |
| DXA-Bone mineral density (pelvis) (UKB data field 23232) | T | β 0.099 | 2E-33 | PubMed |
| DXA-Bone mineral density (legs) (UKB data field 23231) | T | β 0.097 | 5E-32 | PubMed |
| DXA-Bone mineral density (total body) (UKB data field 23236) | T | β 0.092 | 3E-29 | PubMed |
| DXA-Bone mineral density (femur total) (UKB data field 23291) | T | β 0.086 | 9E-26 | PubMed |
| Bone mineral density (spine) | T | OR 0.12 | 5E-25 | PubMed |
| Osteoporosis, osteopenia and pathological fracture (PheCode 743) | C | β 0.075 | 3E-23 | PubMed |
| Osteoporosis (PheCode 743.1) | C | OR 0.1 | 6E-23 | PubMed |
| Osteoporosis NOS (PheCode 743.11) | C | OR 0.1 | 7E-23 | PubMed |
| Osteoporosis (PheCode 743.1) | C | β 0.089 | 2E-18 | PubMed |
| Serum alkaline phosphatase levels | — | β 0.051 | 2E-17 | PubMed |
| Osteoporosis, osteopenia and pathological fracture (PheCode 743) | C | β 0.064 | 2E-17 | PubMed |
| Knee osteoarthritis | T | OR 0.97 | 4E-16 | PubMed |
| DXA-Bone mineral density (arms) (UKB data field 23225) | T | β 0.065 | 2E-15 | PubMed |
| Osteoarthritis | T | OR 0.98 | 3E-13 | PubMed |
| Bone mineral density mean | — | — | 7E-13 | PubMed |
Sources
- dbSNP: rs9533090 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies