Genetic variant
rs9402685
rs9402685 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9402685 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genetic Variants at BCL11A and HBS1L-MYB loci Influence Hb F Levels in Chinese Zhuang -Thalassemia Intermedia Patients.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9402685, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9402685
- Position
- chr6:135098550
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | C | OR 0.18 | 1E-496 | PubMed |
| Mean corpuscular hemoglobin concentration | C | — | 6E-484 | PubMed |
| Mean corpuscular volume | C | OR 0.16 | 2E-420 | PubMed |
| Hematocrit | T | β 0.049 | 4E-336 | PubMed |
| Neutrophil count | C | — | 2E-57 | PubMed |
| Neutrophil count | C | β 0.034 | 1E-52 | PubMed |
| Total cholesterol levels | C | β 0.027 | 5E-51 | PubMed |
| Albumin levels | C | β 0.03 | 5E-42 | PubMed |
| Non-HDL cholesterol levels | C | β 0.024 | 3E-28 | PubMed |
| HEPACAM2 protein levels | C | β 0.053 | 2E-24 | PubMed |
| Eosinophil count | C | β 0.042 | 1E-23 | PubMed |
| Albumin levels | T | β 0.017 | 6E-22 | PubMed |
| ICAM2 protein levels | C | β 0.022 | 2E-21 | PubMed |
| total cholesterol (minimum, inv-norm transformed) | T | β 0.022 | 1E-14 | PubMed |
| Thrombocytopenia (PheCode 287.3) | T | β 0.084 | 1E-13 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | T | β 0.025 | 2E-13 | PubMed |
| Medication use (HMG CoA reductase inhibitors) | C | β 0.034 | 2E-10 | PubMed |
| Mean corpuscular volume | T | OR 0.14 | 1E-9 | PubMed |
Sources
- dbSNP: rs9402685 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies