Genetic variant
rs9399137
rs9399137 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9399137 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9399137, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9399137
- Position
- chr6:135097880
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular volume | — | OR 0.17 | 1E-320 | PubMed |
| Hematocrit | C | β 0.064 | 1E-265 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, mean, inv-norm transformed) | T | OR 0.12 | 1E-265 | PubMed |
| red cell diameter width (RDW, minimum, inv-norm transformed) | T | OR 0.12 | 9E-241 | PubMed |
| Red blood cell count | — | — | 1E-203 | PubMed |
| red cell diameter width (RDW, mean, inv-norm transformed) | T | OR 0.11 | 2E-190 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, minimum, inv-norm transformed) | T | β 0.098 | 1E-186 | PubMed |
| Platelet count | C | β 0.1 | 4E-182 | PubMed |
| Hemoglobin concentration | C | — | 4E-134 | PubMed |
| red cell diameter width (RDW, maximum, inv-norm transformed) | T | β 0.082 | 6E-128 | PubMed |
| Platelet count | — | OR 0.1 | 2E-121 | PubMed |
| Hemoglobin concentration | C | β 0.048 | 2E-112 | PubMed |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transformed) | T | OR 0.17 | 2E-97 | PubMed |
| HDL cholesterol levels (UKB data field 30760) | C | β 0.037 | 2E-94 | PubMed |
| Hemoglobin levels | C | OR 0.42 | 1E-93 | PubMed |
| Mean corpuscular hemoglobin concentration | T | β 0.084 | 3E-90 | PubMed |
| Aspartate aminotransferase levels | T | β 0.027 | 6E-57 | PubMed |
| Blood cell traits latent factor 2 (red cell) | — | — | 7E-53 | PubMed |
| monocyte (absolute count, minimum, inv-norm transformed) | T | β 0.054 | 3E-47 | PubMed |
| Platelet count | C | OR 5.9 | 5E-47 | PubMed |
Sources
- dbSNP: rs9399137 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies